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HPV is the most common sexually transmitted infection, with a reported 79 million persons age 15–59 in the United States currently infected with HPV, and approximately 14 million new cases diagnosed each year. Although most HPV infections are asymptomatic, transient, and do not cause disease, persistent HPV infection can lead to cervical, vulvar, vaginal, anal, penile, and oropharyngeal cancer.
In the United States, approximately 27,000 HPV-attributable cancers occur each year.